Biochemistry
Could more sugar-based drugs be on the way?
Researchers from Denmark have developed a new technique to characterize complex sugar molecules in exquisite detail never before achieved, according to a report published on March 20 in Nature Communications. They hope to leverage the new structural information for the development of therapies.  Discuss
Cryo-EM sheds light on ion channel regulation
A long-standing hypothesis about the regulation of ion channels has been confirmed by cryoelectron microscopy (cryo-EM) imaging. The research presented in Nature on March 18 advances the basic understanding of key cellular processes that can be leveraged for a number of therapeutic and research applications.  Discuss
New lung cancer biomarker could significantly improve patient outcomes
A new protein has been identified on tumor-derived extracellular vesicles that indicates if a lung tumor is likely to metastasize, according to research published in Science Advances on March 11. A minimally invasive biomarker test to catch cancer early could significantly improve patient outcomes.  Discuss
Gene amplification can be responsible for functional innovation in bacteria
Researchers have gained a greater understanding of how gene amplifications rapidly tune levels of gene expression when gene regulation is required but when no other molecular regulatory mechanisms are in place. This research was published in Nature Ecology & Evolution on March 9.  Discuss
New machinery digests toxic proteins to protect DNA replication
Researchers have identified molecular machinery that helps repair damaged DNA that occurs during DNA replication and transcription. This work, published in Nature Communications on March 9, reveals how specific enzymes "eat" or break down proteins that cause broken DNA.  Discuss
Zigzag DNA provides insight into chromosome organization
New Z-loops -- DNA folded into a zigzag structure and guided by essential condensin proteins -- have been caught on camera for the first time. The results of the study provide insight into the organization of chromosomes and were published in Nature on March 4.  Discuss
New NIH study pinpoints how coronavirus attacks cells
The continued spread of the novel 2019 coronavirus, known as SARS-CoV-2, around the world has raised the need for a test to rapidly and efficiently screen coronaviruses to monitor rapid changes and determine how they function. Findings from ongoing U.S. National Institutes of Health (NIH) research, published in Nature Microbiology on February 24, offer new tools in the fight.  Discuss
Genomic landscape of osteosarcomas reveals why immunotherapy may not be effective
Immune profiling of osteosarcoma has revealed why immune checkpoint inhibitors might not be an effective treatment option for patients with this rare type of cancer, according to new research published online February 21 in Nature Communications.  Discuss
Breakthrough in coronavirus research provides map for vaccines
Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Scientists see through human organs for the 1st time
For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.  Discuss
Conferences
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International Europe
July 13-16
Amsterdam, Noord-Holland Netherlands
Bioprocess International West
August 10-13
Santa Clara, California United States
BioProcess International
September 21-24
Boston, Massachusetts United States
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Conferences
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International Europe
July 13-16
Amsterdam, Noord-Holland Netherlands
Bioprocess International West
August 10-13
Santa Clara, California United States
BioProcess International
September 21-24
Boston, Massachusetts United States
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