Biochemistry
Are interferons helpful or harmful during SARS-CoV-2 infection?
The host immune system produces a variety of regulatory molecules, including interferons, during a response to viral infection. Although previously considered beneficial, these proteins may actually cause life-threatening inflammation, according to an article published in Science on June 11.  Discuss
NIH researchers investigate virulence of SARS-CoV-2 virus
What makes the SARS-CoV-2 virus so virulent? Researchers from the U.S. National Institutes of Health (NIH) analyzed the genomics of the virus -- and compared it to other coronaviruses -- in a June 10 article in the Proceedings of the National Academy of Sciences.  Discuss
FDA researchers explore vaccine responses to SARS-CoV-2 antigens
Different proteins associated with SARS-CoV-2, the virus that causes COVID-19, generate unique immune responses when given to rabbits as immunizations, according to a June 8 Science Translational Medicine article.  Discuss
Pioneering technology stabilizes vaccines at all temperatures
Scientists have identified a new method called ensilication to prevent warmed-up vaccines from degrading. By coating proteins in a silica shell, the structures remain intact and effective. A new study published in Scientific Reports on June 8 expands on previous knowledge about the technique and provides crucial in situ and in vivo evidence for real-world applications.  Discuss
Preclinical innovations can speed COVID-19 drug development
Preclinical testing for drug candidates has remained largely unchanged, despite numerous innovations in cell culture techniques. Researchers discussed how these innovations could help speed drug discovery efforts for the COVID-19 pandemic in an article published in Theranostics.  Discuss
Study reveals genomic similarity between SARS-CoV and SARS-CoV-2
A new technique has shown that conserved genetic sequences between SARS-CoV and SARS-CoV-2 may be important for their stability within host cells and ability to infect and replicate efficiently. The methodology was published in Biochemical and Biophysical Research Communications.  Discuss
Reverse genetics allows researchers to map SARS-CoV-2 in the body
A new study has revealed that SARS-CoV-2 infects the nasal cavity to the greatest degree and infects and replicates progressively less well in cells lower in the respiratory tract. The work, including the development of key laboratory tools, has been accepted by Cell.  Discuss
Multiple recombination events may have led to SARS-CoV-2 in humans
A team of scientists evaluating how SARS-CoV-2 jumped to humans found that several genetic recombination events made it especially well-suited to infect humans, according to a study published in Science Advances on May 29.  Discuss
FDA researchers describe lessons learned from COVID-19 immunology
Key immunological factors underlying the clinical stages of COVID-19 that could be targeted by therapeutic drugs were outlined in a review by U.S. Food and Drug Administration (FDA) researchers and published in Frontiers in Immunology on May 29.  Discuss
Virtual framework provides unprecedented detail of the heart
Researchers have created a comprehensive map of cardiac neurons at the cellular scale that allows for gene expression data to be superimposed, giving insight into the functional roles of specific neuron clusters. The work was published in iScience on May 26.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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