Biochemistry
Unveiling bat secrets of immunity could offer clues to treating COVID-19
Bats' longevity and capacity to tolerate viruses may stem from their ability to control inflammation, according to a review article published in Cell Metabolism on July 7. The unique mechanisms that bats employ to achieve this may hold clues to developing new treatments for human diseases.  Discuss
How has SARS-CoV-2 evolved from bat coronavirus?
Structural comparison between a bat coronavirus and SARS-CoV-2 reveals specific characteristics that make the new virus more pathogenic, according to a new article published in Nature Structural and Molecular Biology on July 9.  Discuss
Machine learning helps identify antimicrobial-resistant bacteria
A new graphical user interface-driven, machine learning-based approach has successfully identified antimicrobial resistance genes for gram-positive and -negative bacteria. This work, presented in Scientific Reports on July 3, may make it easier to identify deadly antimicrobial-resistant bacteria.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
DNA 'origami' informs coronavirus vaccine design
Strategically folded DNA arranged to mimic viral antigens -- known as DNA "origami" -- may produce strong immune responses, according to a June 29 report in Nature Nanotechnology. Researchers are now working on adapting this approach for the development of a vaccine against SARS-CoV-2.  Discuss
Getting to the heart of SARS-CoV-2 protease; a main drug target
X-ray crystallography performed at room temperature of the main protease of SARS-CoV-2 may be more physiologically relevant than standard low-temperature x-ray structures, according to a June 24 report in Nature Communications.  Discuss
Computer tools shorten development time for SARS-CoV-2 drugs
Computer-based tools are helping researchers find potentially promising candidates for vaccines and treatments for SARS-CoV-2 -- and much more quickly than traditional approaches. Many of these software tools are described in an article published June 24 in Science Advances.  Discuss
From DNA to precision medicine, researchers discuss breakthroughs in cancer research
From the use of novel technologies such as machine learning and CRISPR, to gaining a deeper understanding of the genetic and molecular drivers of cancer, researchers from around the globe shared their progress with the cancer research community on June 22 at the opening plenary session of the American Association for Cancer Research 2020 virtual annual meeting II.  Discuss
Some viruses may steal host genes to form beneficial hybrid proteins
Certain types of RNA viruses may be capable of using host RNA to expand their own genetic repertoire, according to a new study published in Cell on June 18. This mechanism may enable viruses to overcome the limitations of small genomes and more effectively infect host cells.  Discuss
Cloaked nanoparticles may be a powerful therapy against coronaviruses
Nanoparticles cloaked with human cell membranes can attract and neutralize SARS-CoV-2, according to a new publication in Nano Letters on June 17. The process of binding to the virus hijacks its ability to replicate, making it a viable medical countermeasure against the virus.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
General Discussion
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Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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