Bioimaging & Microscopy
Scientists see through human organs for the 1st time
For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.  Discuss
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22.  Discuss
Scientists in the Lab: Featuring Nicole Lindor
ScienceBoard is happy to continue to feature scientists in the lab this month. The next scientist we are featuring is Nicole Lindor, a doctoral candidate at North Carolina State University.  Discuss
Improving melanoma immunotherapies by regulating Treg proliferation
A new pathway to regulating anti-tumor immunity and increasing the effectiveness of PD-1 therapies was identified by scientists at Sanford Burnham Prebys Medical Discovery Institute. The results were published in Nature Communications on January 7.  Discuss
New imaging technique gains an advantage with deep learning software
Researchers from Rensselaer Polytechnic Institute developed a new technique that applies deep learning to quantify images generated from fluorescence lifetime imaging. Details of the deep neural network they developed, called FLI-Net, are described in the November 12 issue of the Proceedings of the National Academy of Sciences.  Discuss
Super-resolution using standard optical microscopes now possible with the aid of upconversion nanoparticles
Researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) in Australia have found an innovative way to utilize standard laboratory optical imaging equipment to bypass diffraction limitations and achieve super-resolution. Results published in Nature Communications on August 16 provide methodology and theoretical framework for end-users to achieve super-resolution in their own laboratories.  Discuss
Visualizing big data in the life sciences gets an upgrade with new software
A new software developed by researchers at the Max Delbrück Center for Molecular Medicine (MDC) uses algorithms to reconstruct and scale data acquired by light-sheet microscopy that renders a supercomputer unnecessary. Light microscopy techniques provide extremely detailed information but result in terabytes of data which is nearly impossible for scientists to process. MDC researchers are helping make sense of this data.  Discuss
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Conferences
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
Lab of the Future USA
May 19-20
Boston, Massachusetts United States
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International
September 21-24
Boston, Massachusetts United States
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Conferences
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
Lab of the Future USA
May 19-20
Boston, Massachusetts United States
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International
September 21-24
Boston, Massachusetts United States
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