Bio-Imaging & Microscopy
Innovations in 3D printing lead to implantable blood vessels
Using bioinks formulated from smooth muscle cells from a human aorta and endothelial cells from an umbilical vein, researchers built a biomimetic blood vessel using 3D printing techniques.  Discuss
New bio-imaging techniques help scientists understand the early stages of Parkinson's disease
Scientists observed, for the first time ever, how variants of Parkinson's disease-associated protein alpha-synuclein change over time and identify the initial stages of protein aggregates. A new study published in Nature Communications on October 10 helps to clarify the why treatment challenges associated with Parkinson's disease (PD), when does it begin.  Discuss
Protein receptors imaged by cryoelectron microscopy help scientists understand inflammation
Researchers at Oregon Health & Science University used cryoelectron microscopy (cryo-EM) to observe protein structure and function at a molecular level. This discovery, published in Cell on October 3 describes the structure of P2X receptor, a cellular membrane protein receptor, and provides insight into how the cation channel functions.  Discuss
Understanding bacterial motility using cryogenic electron microscopy
A new finding reported in Nature Structural & Molecular Biology on October 1 shows how bacterial transmit motion from an inner motor to an outer tail through a flexible joint in the flagellum. This hook helps researchers understand how bacteria move and allows them to improve therapies against bacterial infections.  Discuss
Super-resolution imaging characterizes individual synaptic proteins
It is now possible to rapidly image synaptic proteins at high-resolution thanks to a new technique developed by researchers at MIT and the Broad Institute of Harvard. Details of the technique which use fluorescent nucleic acid probes to label different proteins are described the September 26 Nature Communications article.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
Novel "death star" nanoparticle discovered for potential use in targeted therapies
A novel nanoparticle has been reported by researchers at San Diego State University with the potential to serve as a delivery system for therapeutics. The research published on September 17 in eLife describes how Metamorphosis Associated Contractile structures (MACs) trigger metamorphosis in tubeworms. Moreover, they identify a novel protein (with syringe-like structures, nicknamed Death Star for the effect it has) responsible for the activation of metamorphosis.  Discuss
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th.  Discuss
Fluorescent molecular probe used to detect temperature inside individual cells
Modified biocompatible molecular rotor, termed boron dipyrromethene (BODIPY), has been shown to detect temperatures inside single cells. Researchers at Rice University led by chemist Angel Mart√≠ published the technique in the Journal of Physical Chemistry B.  Discuss
Super-resolution using standard optical microscopes now possible with the aid of upconversion nanoparticles
Researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) in Australia have found an innovative way to utilize standard laboratory optical imaging equipment to bypass diffraction limitations and achieve super-resolution. Results published in Nature Communications on August 16 provide methodology and theoretical framework for end-users to achieve super-resolution in their own laboratories.  Discuss
Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
Medlab Middle East
February 3-6, 2020
Dubai, Dubai United Arab Emirates
Japan Analytical & Scientific Instruments Show (JASIS)
November 11-13, 2020
Chiba, Chiba Japan
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Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
Medlab Middle East
February 3-6, 2020
Dubai, Dubai United Arab Emirates
Japan Analytical & Scientific Instruments Show (JASIS)
November 11-13, 2020
Chiba, Chiba Japan
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